How long is nitroglycerin sublingual tablets stable after opening the container?

How long is nitroglycerin sublingual tablets stable after opening the container?

• A. 6 months
• B. 12 months
• C. 30 days
• D. 90 days

Answer: (A)

Nitroglycerin sublingual tablets are highly sensitive to light, moisture, and air. Once the container is opened, the tablets begin to degrade in potency, so a limited stability window is given. The standard guidance is that nitroglycerin tablets should be discarded six months after opening the bottle, even if they appear okay, to ensure reliable effectiveness when treating angina. Store the bottle in its original amber container, kept tightly closed, at room temperature and away from heat and moisture (not in the bathroom). The other timeframes are not supported by stability data: a year after opening would risk reduced potency, while 30 or 90 days are too short for typical consumer use.

Nitroglycerin sublingual tablets are highly sensitive to light, moisture, and air. Once the container is opened, the tablets begin to degrade in potency, so a limited stability window is given. The standard guidance is that nitroglycerin tablets should be discarded six months after opening the bottle, even if they appear okay, to ensure reliable effectiveness when treating angina. Store the bottle in its original amber container, kept tightly closed, at room temperature and away from heat and moisture (not in the bathroom). The other timeframes are not supported by stability data: a year after opening would risk reduced potency, while 30 or 90 days are too short for typical consumer use.